ASSESSMENT OF MULTIPLE AREAS ON MAGNETIC RESONANCE MIDSAGITTAL BRAIN IMAGES IN MULTIPLE SCLEROSIS PATIENTS* RENGIN KOSIF, SULE AYDIN TURKOGLU, ELIF SULTAN BOLAC and EMINE DAGISTAN

Multiple sclerosis (MS) is a chronic immune mediated, inl ammatory, demyelinating disease of the central nervous system (1). New magnetic resonance imaging (MRI) techniques have shown microstructural damage either at white matter or gray matter, proven to be of histopathologic nature (2). Inl ammation in MS has been proven, especially in deep white matter, gray matter and interstitial area, so atrophy occurs globally. Atrophy studies performed in MS have revealed the global cerebral volume, white matter and gray matter to be decreased (3). Cortical atrophy has been shown to be more pronounced than atrophy of the gray matter fraction and white matter fraction, also showing slight correlation with the Expanded Disability Status Scale (EDSS) score (4). It has been observed that the most frequent atrophy type is cortical atrophy and corpus callosum atrophy; also, hippocampal atrophy is much notable than global brain atrophy and continues progressively (5).